Self-Healing Hydrogels via Reversible Covalent Cross-Links Considering applications in which stiffer hydrogels are necessary, developing systems containing covalent cross-links may be required. Adhesive and Shape-Memory Polymers for Tissue Repair and Replacement Fast annealing, adhesive bioinspired polymers are interesting materials for on-site repair of existing tissues. Figure 6. Conclusions for Structural Dynamics of Polymer Assemblies Within the past several decades, interest in dynamic biosynthetic polymers has expanded and with it new approaches to develop materials that encompass both the complex functions intrinsic to natural biomolecules and tunable capabilities like stimuli responsiveness constructed in synthetic polymers.
Biotherapeutic Stabilization: Storage, Release, and Bioresistance The widespread availability of biotherapeutics such as therapeutic peptides and proteins, antibodies, engineered fusion proteins, and conjugates has been used to treat conditions including cardiovascular disease, cancer, inflammation, infectious diseases, and genetic disorders. Matrix-Based Assemblies for Biopolymer Storage Hydrogels are one of the most heavily investigated biomaterials for enzyme stabilization and controlled release of small molecule drugs, nanoparticles, and biotherapeutics, due to simple syntheses.
Bioresistance with Biopolymer Conjugates Polymer conjugation has been a successful method for prolonging the circulation half-life and activity of unstable biopolymers. Figure 8. Conclusion for Biostabilization Expensive biomolecules and biotherapeutics often suffer from instability and rapid degradation or clearance.
Conclusions and Outlook The divide between pure synthetic and natural macromolecules continues to narrow in the pursuit of biologically relevant materials with increasingly complex functionality. Notes The authors declare no competing financial interest. History of Post-Polymerization Modification.
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